Suminat Nasal Spray is usually a drug that may be applied to treating migraine attacks following or absent the presence associated with the aura, to alleviate cluster headache attacks. Its active component Sumatriptan is known as a Specific and selective agonist of 5-HT1-serotonin receptors localized mainly in veins of those brain. Migraine headaches are said to get stipulated by widening of blood vessels in the brain. Sumatriptan causes vasoconstriction of the carotid arterial bed which provides extracranial and intracranial tissues with blood with out a significant affect on cerebral flow of blood. It may also inhibits workings of receptor that answerable for transmission of pain signals by nerves into the brain.

Dosage and direction
Take Suminat Nasal Spray along at the first sign of any migraine headache. Each spray contains 20mg dose of your active substance. One dose of your spray is directed by spraying the medication up one nostril. Second application in two hours following the first one be approved into your doctor in the event the warning signs a migraine persists. Follow all institutions within your doctor. Tend not to exceed the dose which was recommended to you personally.

Precautions
Take Suminat Nasal Spray made use of just to treat an acute, classic migraine attack or perhaps a cluster headache, it should not be accustomed for remedy for certain unusual kinds of migraine. Patients with uncontrolled elevated blood pressure need not to use Sumatriptan.

Contraindications
Hypersensitivity, basal, ophtalmoplegic, hemiplegic forms of migraine, ischemic heart disease (including suspected it), angina (including angina Printsmetala), myocardial infarction (also in history), hypertension, peripheral arterial occlusive disease, stroke or transient cerebrovascular accident (are found in history), liver and kidney failure. Cautiousness ought to be exercised in patients with epilepsy (including any condition with low epileptic threshold), hypertension, pregnancy, breastfeeding, in infants and adolescents (younger than 18 y.o.), in patients older than 65 y.o.; simultaneous intake of medications which contain ergotamine and derivatives, MAO inhibitors, also while in the time 14 days after their cancellation.

Possible side effect
This medication is often well tolerated and adverse reactions aren’t expected. Most frequent unwanted effects include nasal irritation, pain or tightness in the chest or throat, tingling, flushing, weakness, dizziness, muscle cramping, diarrhea, abdominal discomfort, sweating, nasal irritation, and injection site reactions. Aversions as adverse reactions of organism to Sumatriptan are also possible.

Drug interaction
Co-administration with ergotamine and medications containing ergotamin may program a continued spasm of blood vessels (the interval between administration of these medications need to be not less than 24 h). Interaction of Sumatriptan and MAO inhibitors (isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane)) is additionally possible leading to increased concentration of Sumatriptan. Concomitant utilization of Sumatriptan with selective serotonin reuptake inhibitors or SSRIs, including fluoxetine (Prozac), citalopram (Celexa), paroxetine (Paxil), and sertraline (Zoloft) or serotonin and norepinephrine reuptake inhibitors, including venlafaxine (Effexor), duloxetine (Cymbalta), and desvenlafaxine (Pristiq) may promote weakness, hyperreflexia and poor coordination of movements.

Missed dose
Take Suminat Nasal Spray will never be suitable for regular use, it truly is taken only during an attack.

Overdose
Be especially conscious of such symptoms as bluish tinge into the skin, convulsions, dilated pupils, inactivity, absence of coordination, paralysis, redness within the limbs, skin changes for the site of injection, slow breathing, sluggishness, tremor as they definitely can be indications of Sumatriptan overdose. Inform your health care advisor immediately about your condition nor look for emergency medical help.

Storage
Store this medication for a temperature of 2-30 C (36-86 F) inside a tight container proof against light and moisture.