Lozol is usually a thiazide-like diuretic consists of any kind of substance benzamide-sulfonamide-indole (Indapamide). By its pharmacological properties it truly is similar to thiazide diuretics (changes of Na re-absorption within the vertical segment of the loop of Henle). Lozol increases excretion of Na , Cl-, K , and Mg2 with urine. It really is used to treat hypertension either alone as well as combination with other elevated blood pressure medications. Long treatment with Lozol is required, a therapeutic effect observed after 1-2 weeks of use, maximum has been achieved in 8-12 weeks and maintains to 8 weeks.

Dosage and direction
Take Lozol once each day in mornings before breakfast following or absent food. The usual initial dose is 1.25 mg taken as a single daily dose. This can be increased approximately 5 mg.

Precautions
Lozol along with diuretics stimulate excretion of slats and potassium with urine which may cause considerable loss of the substances especially among elderly women. Hypopotasse signs are muscle weakness and rapid or irregular heartbeat. For compensation of your potassium loss, you may well be recommended consuming potassium-rich foods or using a potassium supplement. Likelihood of hypopotassemia increases when larger doses are utilized, inside the patients with cirrhosis, as well as in those treated by corticosteroids or ACTH. Venous pressure, K serum, and creatinine tests must be carried out regularly, especially within the those with an irregular heartbeat or those on heart medications. Systematic management of blood K , Na , Mg2 , pH, glucose uric acid and residual nitrogen is called for especially in patients with gout or high uric acid levels, liver disease, diabetes, or lupus erythematosus, kidney dysfunction.

Contraindications
Lozol cannot be administered in patients with hypersensitivity to its components, severe liver or kidney failure (anuria), hypopotassemia. Excessive amounts of Lozol must not be used to treat edematous syndrome inside the patients with cerebrovascular accident and decompensated diabetes with ketoacidosis. Lozol can’t be used in individuals with lactose intolerance, galactosemia, a syndrome of glucose malabsorption of the medication which have lactose. Cautiousness ought to be exercised in those with impairments of water-electrolyte balance, moderate liver or kidney failure, ascites, coronary artery disease, heart failure, hyperuricemia (gout), hyperparathyroidism, pregnant or breastfeeding women in elderly or adolescents under 18 years of age.

Possible side effect
Frequency of negative effects depends on the dose of Lozol. They need to appear as agitation, anxiety, dizziness, headache, sciatica, diarrhea, vomiting, abdominal pain, dry mouth, infection, irritability, muscle cramps or spasms, numbness in hands and feet, nervousness, nasal inflammation, pain, tension, fatigue, weakness, loss of energy or tiredness.

Drug interaction
Lozol could generate hypopotasseimia and hypomagnesemia. Fatal arrhythmias may develop in patients on digoxin (Lanoxin) as a consequence of toxicity. Cardiac arrhythmias can also be attributable to utilization of amiodarone (Cordarone) and indapamide. Elimination of lithium by kidneys decreases in patients treated by diuretics and hereby results in increase of lithium toxicity.

Missed dose
Never use a double dose in this medication. Whether it is almost time of many next dose just skip the missed portion and perpetuate to opt for the medication in line with the schedule.

Overdose
You will need immediate medical assistance in case of Lozol overdose which might express through such symptoms as electrolyte imbalance, nausea, stomach disorders, vomiting, weakness.

Storage
Tablets of Lozol probably will be stored at room temperature between 15-30 C (59-86 F).