Glucophage is definitely an oral diabetes medicine made use to treat type 2 of diabetes. Its active substance is Metformin which is a member of biguanide theme of substances. It reduces concentration of glucose in blood suppressing metabolism of glucose in the liver, reducing absorption of glucose that come from the gastrointestinal tract, and enhancing its utilization in tissues. Glucophage stabilizes or reduces heavy. The therapeutic effect is not observed in the absence of insulin within the bloodstream. It does not cause hypoglycemic reactions. It improves fibrinolytic properties of blood. It I got to treat diabetes mellitus (type 2) in adults are in patients for who treatment with sulfonylurea was ineffective, especially in cases utilized by obesity.

Dosage and direction
Do not take if this medication haven’t been prescribed to you personally and don t exceed the recommended dose. Take it which has a meal in case your doctor could not recommend anyone to go differently. Glucophage is handled for taking twice daily by 500 mg or 850 mg once daily take away type 2 diabetes in adults. Basing on the sugar levels available in the blood the dose of Glucophage may well be increased to your maximum daily dose of 2550 mg given in three divided doses.

Precautions
This medication is able to cause a dangerous condition in some people and that is characterized by weakness, increasing sleepiness, slow heartbeat, cold feeling, muscle pain, abdominal pain, shortness of breath, feeling light-headed, and fainting. Its called lactic acidosis. Should you experience such symptoms get immediate medical help. Also be attentive to warning signs low blood sugar level which includes hunger, confusion, irritability, drowsiness, headache, weakness, fast heartbeat, tremors, sweating, seizure and maybe have a way to obtain sugar accessible always. Avoid drinking alcohol.

Contraindications
Hypersensitivity, hyperglycemic coma, ketoacidosis, kidney failure, liver disease, heart failure, acute myocardial infarction, respiratory failure, dehydration, infectious diseases, extensive surgery and trauma, alcoholism, reduced-calorie diet (less than 1000 kcal / day), lactic acidosis (including history), pregnancy, breastfeeding. The drug will not be prescribed to move 2 days before a surgery, radioisotope and X-ray examinations, CAT scanning (CT). Glucophage is contraindicated in patients over 60 y.o., or doing hard physical work (risk of lactic acidosis increases).

Unwanted effects
The subsequent side effects are most common and be rather severe to halt taking of a typical medication: swelling or rapid weight, nausea, vomiting, gas, bloating, diarrhea and absence of appetite. For when of lactic acidosis will also get emergency medical help: weakness, increasing drowsiness, slow heartbeat, cold feeling, shortness of breath, abdominal pain, muscle pain, lightheadedness, and fainting. Allergic reaction can be possible: hives, swelling, rash.

Drug interaction
Cimetidine (Tagamet) increases blood stages of Glucophage affecting its metabolism. Glucophage is not appropriate for alcohol. Concomitant administration with indirect anticoagulants and Cimetidine must be carried out with cautiousness. Glucophage enhances metabolism of Furosemide. Derivatives of sulfonylurea, insulin, acarbose, inhibitors of MAO, oxytetracycline, cyclophosphamide and salicylates raise the outcome of Glucophage. Decrease of hypoglycemic effect of Glucophage is caused by co-administration with thyroid medicines, contraceptive pills as well as other hormones, Epinephrine, Glucagon, thiazide diuretics, nicotinic acid derivates.

Missed dose
If you forgot to move your dose in your time, please practice it as soon as you remember. But don’t take whether it is delayed or time for your next dose is contained in a long time. Don’t take double doses in this medication or extra doses of it. Take your usually dose next day by the same regularly time.

Overdose
Warning signs Glucophage overdose are ones of low blood sugar: hunger, confusion, irritability, drowsiness, headache, weakness,, tremors, sweating, fast heartbeat, seizure and maybe have a source of sugar accessible always. In the event you experience one instance or any unusual symptoms call your health care provider immediately.

Storage
Store at room temperature between 20-25 C (68-77 F). Store from the moisture, heat, and sunlight. It isn’t recommended to store within a bathroom and places an alternative for children.